- 229Th Generator Production of 225Ac at Oak Ridge National Laboratory
May 16, 2019
Oak Ridge National Laboratory
- Cathy Cutler Wins Brookhaven Town's 2019 Women in Science Recognition Award
April 16, 2019
Brookhaven National Laboratory Newsroom
- Pre-clinical Evaluation of 225Ac-DOTATOC Pharmacokinetics, Dosimetry, and Histopathology to Enable Phase-1 Clinical Trial in Patients with Neuroendocrine Tumors (PDF)
Radiopharmaceutical Sciences Program, University of New Mexico Health Sciences Center, UNM Comprehensive Cancer Center, Invicro, Los Alamos National Laboratory
- Dosimetric Impact of Ac-227 in Accelerator-Produced Ac-225 (PDF)
Johns Hopkins School of Medicine, Radiopharmaceutical Imaging and Dosimetry, LLC, Actinium Pharmaceuticals, Inc
- Radiolabeling of DOTA-conjugated Lintuzumab with 225Ac: Comparison of 229Th-produced and High-Energy Proton Accelerator-produced 225Ac (PDF)
University of Saskatchewan, Actinium Pharmaceuticals, Inc
- How Do You Want Your Isotope? (PDF)
- Isotopes to the Rescue (PDF)
- Radiation, Meet Cancer Cell (PDF)
June 2017: Isotopes Routinely Available: radium-223 and thorium-227
May 2017: Attend the DOE Isotope Program User Meetings
May 2017: DOE Isotope Program Announces the Availability of Additional Isotopes
May 2017: Announcing a Temporary Assignment Opportunity in the DOE Isotope Program - Headquarters (Germantown, MD)
September 2016: Quality Assurance Position Opening in the National Isotope Development Center (NIDC)
August 2016: The DOE Office of Science Graduate Student Research (SCGSR) program is now accepting applications!
August 2016: Isotope Program Stakeholders Meeting
May 2016: At-211 Partnership Agreement for University Isotope Production Finalized
May 2016: DOE Isotope Program in the Office of Nuclear Physics has posted a new funding opportunity announcement for Research, Development and Training in Isotope Production
May 2016: Special Notice: Private Sector Survey Form Available
April 2016: From the BNL Newsroom: Boosting Production of Radioisotopes for Diagnostics and Therapeutics
April 2016: Advances in Nuclear Nonproliferation Technology and Policy Conference: Bridging the Gaps in Nuclear Nonproliferation, September 25-28, 2016
March 2016: Quality Assurance Position Opening in the National Isotope Development Center (NIDC)
February 2016: The 16th International Workshop on Targetry and Target Chemistry Workshop (WTTC16) is Now Open for Abstract Submission
February 2016: The DOE Office of Science Graduate Student Research (SCGSR) Program is Now Accepting Applications
January 2016: New Program Manager for Isotope Initiatives
December 2015: NBC Nightly News Segment Highlights Ac-225 Production at LANL and Development of Alpha-Immunotherapy
On Dec. 16, NBC Nightly News featured the following news segment on Ac-225 Production at LANL and development of alpha-immunotherapy. You can visit the news story here: Los Alamos Turns Its Nuclear Weapons Power to War on Cancer
December 2015: Isotope Program Sr-89 Samples Available for Evaluation
August 2015: Isotope Program Stakeholders Meeting
August 2015: DOE/NSF Nuclear Science Advisory Committee (NSAC) Report
July 2015: Call for Evaluation Studies for Dosimetry/Toxicity Analysis of Accelerator-Produced Actinium-225 (Ac-225)
July 2015: Student Bursaries Available for Attending Radiochemistry-Related Symposia
June 2015: Isotope Program Video Released
May 2015: NIDC Has Launched New Online Quotation and Ordering Feature for Stable Isotope Research Customers
May 2015: NIDC Launching New Online Quotation and Ordering Feature for Stable Isotope Research Customers
May 2015: New Email and Mailing List Addresses for the NIDC.
[Updated] May 2015: DOE Isotope Program Announces Opening - Program Manager for Isotopes Facilities
May 2015: DOE Isotope Program Will Not Auction Helium-3 in 2015.
Please click here for more information.
April 2015: DOE Isotope Program Announces Tungsten-188 (W-188) Is Now Available!
April 2015: DOE Isotope Program Announces Restart of Bulk High Specific Activity (HSA) Co-60 Production
March 2015: DOE Isotope Program Announces Opening - Program Manager for Isotopes Facilities
March 2015: DOE Isotope Program Announces Availability of Radium-224/Lead-212 Generators
January 2015: Abstracts are now being accepted for Pacifichem 2015 in Honolulu, Hawaii, December 15-20, 2015
January 2015: NIDC Isotope Program Bk-249 Availability - Request a Price Quotation by Jan. 30, 2015
November 2014: Isotope Program Customer Meetings - Make Arrangements for Your Meeting by Dec. 5, 2014
August 2014: LANL Employee Spotlight Article on Jonathan Engle
August 2014: Bidding is Now Open for the Summer 2014 Helium-3 Auction
July 2014: Microgram Quantities of Berkelium-249 Available
July 2014: Applications Being Accepted for the SCGSR Program
July 2014: The International Chemical Congress of Pacific Basin Societies will hold Pacifichem 2015 in Honolulu, Hawaii, December 15-20, 2015
June 2014: Leonard Mausner of Brookhaven Lab's Collider-Accelerator Department Granted Tenure
June 2014: Funding Opportunity Announcement DE-FOA-0001136: Leveraging Isotope Program Resources and Enhancing Facilities for Isotope Production and Research
May 2014: Televised Interview with ORNL Nuclear Engineer Julie Ezold
April 2014: New Video Highlights the Cf-252 Production Program at ORNL
April 2014: New Video Highlights Isotope Production at LANL
March 2014: Research, Development, and Training in Isotope Production
February 2014: Targeted Radiochemistry and Associated Technology Development for Integrated Nuclear Medicine Research and Training with Human Application
September 2013: Bidding is Now Closed for Summer 2013 He3 Auction
August 2013: Summer 2013 He3 Auction in Progress
July 2013: FedBizOpps Announcement Released for He-3 Auction in Summer 2013
The DOE Isotope Program is Pleased to announce an upcoming auction for 4,000 liters of He-3 gas. Please see this FedBizOpps.gov (Federal Business Opportunities) web link for more details.
July 2013: He-3 Auction in Summer 2013
For the second year, DOE is planning to conduct a Helium-3 (He-3) auction. 4,000 liters of He-3 gas will be available for bids in a process similar to the one conducted late in 2012. DOE's Invitation for Bids (IFB) for the purchase of He-3 gas is scheduled to be posted for viewing and downloading on the NIDC website by August 9, 2013.
After the Invitation for Bids is issued, DOE will accept questions submitted to the following email address: He3auction@science.doe.gov, no later than 5 PM (Eastern Daylight Time), on August 23, 2013. The Bid process is currently slated to come to a close on September 17, 2013.
July 2013: Copper-67 Shipments are Scheduled for July 23, 2013
A Copper-67 (Cu-67) production run is scheduled for this month, with shipments scheduled to occur on July 23, 2013. The Cu-67 is priced at $295.00 per millicurie, plus $300.00 for packaging.
Please contact Mitch Ferren (email address firstname.lastname@example.org) of the Isotope Business Office by COB Monday, July 15, 2013, if you are interested in purchasing material.
February 2013: ORNL begins implementation of new Californium-252 production contract
OAK RIDGE, Tenn., Feb. 28, 2013 -- The Department of Energy's Oak Ridge National Laboratory - home of one of only two reactor facilities in the world capable of producing Californium-252 (Cf-252) - has begun implementing a new six-year contract between the DOE Isotope Program and industry to make this unique and versatile radioisotope.
The new contract follows the successful completion of a four-year Cf-252 program under an agreement with a consortium of industries that use the neutron emitting radioisotope for a number of applications that focus mostly on analysis, detection and nuclear energy.
"Californium-252 serves as a unique, portable neutron source," said Julie Ezold, who manages ORNL's Cf-252 production program. "A cross-cut of industries including coal, oil and mineral companies rely on it for critical applications, and it is used in defense and national security applications."
The radioisotope is critical to a number of energy and security related tasks. The coal industry uses Cf-252's neutron emissions to detect impurities in coal; the construction industry performs similar analysis on cement. The oil industry sends the radioisotope down well shafts to determine the well's potential productivity. Cf-252 is also used to calibrate radiation detection instruments including those used in worldwide port security operations. The powerful neutron emitter is also used to start up dormant naval and commercial nuclear reactors.
ORNL's High Flux Isotope Reactor (HFIR) is one of only two reactors in the world with sufficient neutron production, or "flux," to irradiate Curium targets to produce Cf-252. The irradiated targets are then processed in the adjoining hot cells at the Radiochemical Engineering and Development Center (REDC).
The only other facility capable of producing Cf-252 is in Dimitrovgrad, Russia. Cf-252 produced at ORNL supplies approximately 70 percent of global demand for the material.
Cf-252 results from a complex process that begins with the irradiation of a Curium target in HFIR, followed by several steps involving chemical processing and purification at the REDC and fabrication of new Curium targets. The process includes the production of several precursor radioisotopes; in fact, the Cf-252 program enabled the production of the Berkelium-249 used in the U.S.-Russia collaboration that discovered element 117, announced in 2010.
The work is funded through the DOE Isotope Program within the DOE Office of Science. The Office of Science and the consortium finalized the new, six-year contract in November.
"With HFIR, REDC and the unique nuclear engineering capabilities they provide, the DOE Isotope Program is able to supply a global, billion-dollar industry with a critical material," Ezold said. "This one-of-a-kind direct contract with industry makes possible work that is important to our energy sector and to global security."
ORNL is managed by UT-Battelle for the Department of Energy's Office of Science.
DOE's Office of Science is the single largest supporter of basic research in the physical sciences in the United States, and is working to address some of the most pressing challenges of our time. For more information, please visit science.energy.gov.
MEDIA CONTACT: Bill Cabage
cabagewh at ornl.gov
December 2012: Medical Isotope Legislation Update
The American Medical Isotopes Production Act, first introduced in 2009 to provide federal assistance for the domestic production of the medical isotope molybdenum-99 (Mo-99,) could be enacted as part of the much larger National Defense Authorization Act for FY 2013. This bill is scheduled to go to a conference in the near future before its final passage by the House and Senate. Please click here to learn more about the bill
Please click here to learn more about the bill. For an update from the American Institute of Physics on the status of the bill, Please click here.
November 2012: Update on U.S. Helium Program and U.S. Production of 99-Molybdenum
The American Institute of Physics has a press release regarding the U.S. Helium Program and U.S. Production of 99-Molybdenum. It includes a discussion of a recent report by the Office of the Inspector General of the U.S. Department of the Interior, recent hearings in the U.S. Senate and House of Representatives, the "Energy Critical Elements Advancement Act", and the production of 99-Mo via a linear accelerator. Please click here to read the AIP press release.
November 2012: Bidding Closed for He3 Auction
Bidding has closed for the Fall 2012 He3 Auction. For more details on the auction, Please see our page http://isotopes.gov/he-3auction2012
Please see our page http://isotopes.gov/he-3auction2012.
October - November 2012: He3 Auction -- Bids Now Accepted
Bids are now being accepted for the DOE auction of Helium-3 gas. All valid bids to purchase He-3 gas must be received by the U.S. Department of Energy no later than 5 PM, local prevailing time (Washington, DC) on November 14, 2012. To submit a bid, and to see more information on the auction, Please see our page http://isotopes.gov/he-3auction2012.
September 2012: He3 Auction in Fall 2012
DOE is now accepting questions regarding an Invitation for Bids for a Helium-3 auction in Fall 2012. All questions must be submitted to the email address He3auction@science.doe.gov no later than 5 PM on October 23, 2012. DOE will respond to all questions by 5 PM, October 26, 2012. DOE will post all questions received and their corresponding answers on the web page http://isotopes.gov/he-3auction2012. The identity of the stakeholder posing the question will be kept anonymous and will not be posted on that web page.
July 2012: DOE Early Career Research Program
The DOE Funding Announcements for the 2012 Early Career Research Program are now available at http://science.energy.gov/early-career/.
The schedule is as follows:
Due date for Pre-applications: 6-Sep-12, 5 pm eastern time
Encourage/Discourage Decisions: 4-Oct-12
Due date for Proposals: 26-Nov-12, 5 pm eastern time
Note that preapplications from everyone and lab proposals from DOE national laboratories must be submitted directly in the Portfolio Analysis and Management System (PAMS) this year. That means all Principal Investigators MUST register and create accounts in PAMS. Interested PIs are encouraged to register right away. Registration information is in the solicitations and FAQs. Due times are 5 pm this year (instead of the usual 11:59 pm) to take advantage of the PAMS help desk hours.
March 2012: Survey Form for Private Sector on Future Isotope Needs
The NIDC is requesting that companies complete and submit this survey form and return to Wolfgang Runde [email@example.com] by March 30, 2012. Information should be submitted even if the potential need for an isotope is somewhat uncertain for the coming years. If a specific isotope is not identified or requested by anyone, it may not be considered for production or production development by the IDPRA during fiscal years 2012-2016. For more information see our Newsletters page.
Please send any suggestions for news items to firstname.lastname@example.org.