| NIDC: National Isotope Development Center

Save the date for the DOE National Isotope Summit

The U.S. Department of Energy Office of Isotope R&D and Production will host the National Isotope Summit February 1–4, 2027, in Washington, DC.

The summit will provide a forum for aligning isotope demand, supply capabilities, investment in scientific discovery, and federal priorities. Click here to express your interest in attending and receive updates as more information becomes…

U.S. Department of Energy Advances Domestic Capabilities for Producing Quantum Materials

Under the guidance and funding of the Office of Isotope R&D and Production, Pacific Northwest National Laboratory has developed systems that can convert commercially available, isotopically enriched, silicon and germanium materials into high-purity silane (SiH₄) and germane (GeH₄). …

DOE Expands Stable Isotope Production Capabilities at Oak Ridge National Laboratory

The U.S. Department of Energy (DOE) Office of Science’s Isotope R&D and Production (IRP) program has re-established and revolutionized its domestic stable isotope enrichment capabilities. Led by pioneering advancements at Oak Ridge National Laboratory (ORNL), this expansion stabilizes the national isotope market, reducing…

Isotope Product Catalog

With 225+ isotopes available for purchase, the U.S. Department of Energy Isotope Program is the world leader in quality, purity, and availability of the most sought after and rare isotopes.

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Translating Research to Applications

Get a behind-the-scenes look at the production of isotopes across the Department's facilities that are critical to everyday applications, particularly in the medical arena.

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Medical Isotopes

With more than 35 medically relevant isotopes available and others under investigation, the NIDC is committed to supplying the world with the highest quality isotopes for medical use.

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Technical Resources

Need a custom service for your order? We offer a wide variety of special services to complement our radioactive and stable isotope offerings.

Technical Resources

Our mission is to support the U.S. Department of Energy Isotope Program as the global leader in the production and distribution of radioactive and enriched stable isotopes that are deemed critical or are in short supply.

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NIDC News

Join us for Fall Stakeholder Meetings

The Department of Energy’s Office of Isotope R&D and Production, within the Office of Science, invites you to take part in virtual stakeholder meetings on Oct. 13, Oct. 14, and in-person at the EANM Annual Congress on Oct. 19.

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Come Join the DOE Isotope Team

DOE’s Office of Science has one intern position available in the Office of Isotope R&D and Production (IRP), located at DOE Headquarters (Washington, DC) or DOE Germantown (Germantown, MD).

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Discover Science: Applications Open for Spring 2027 Undergraduate Internships

The Department of Energy is accepting applications for the Spring 2027 term to the Science Undergraduate Laboratory Internships program and the Community College Internships program.

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DOE Isotope Program Highlights

Steps in terbium-161 (Tb-161) production. The University of Utah TRIGA reactor induces thermal neutron capture on gadolinium-160 (Gd-160), which decays to Tb-161. Separating the Gd-160 target yields high-purity Tb-161 for cancer therapy and diagnosis. Graphic courtesy of Connor Holiski.

To Advance Cancer Therapy, University Starts Producing Terbium-161

September 16, 2025

In this study, researchers from the University of Utah, in collaboration with the University of Missouri, produced Tb-161 using the University of Utah’s TRIGA research reactors.

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Improvements to Americium-241 processing can increase yield, decrease the amount of waste generated, and reduce the radiological dose workers receive. Image courtesy of Brittany St. Jacques, Los Alamos National Laboratory

Improving Large-Scale Domestic Production of Americium-241, a Critical Component in Smoke Detectors and Nuclear Batteries

July 23, 2025

Researchers explore the effects of radiation and harsh chemicals to optimize americium-241 production.

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Image courtesy of Jon Burns, University of Alabama at Birmingham Schematic of the astatine-ketone bond breaking to release free astatine-211.

Astatine Paving the Way for a New Era in Cancer Radiopharmaceuticals

July 16, 2025

Researchers gain new insights into a strong bond between At-211 and common chemicals, creating new possibilities for cancer treatment

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Image courtesy of Chris Orosco/ORNL, U.S. Dept. of Energy Artists’ depiction of a new potential cancer treatment vehicle—an engineered nanometer-size construct that holds a radioactive isotope that can be delivered to destroy cancer cells.

Killing Cancer with Radioactive Nanocrystals

June 24, 2025

The Department of Energy Isotope Program (DOE IP) continues to enable groundbreaking developments in cancer research through the provision of medically relevant isotopes.

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Upcoming Events

October

17–21

2026

EANM'26 Annual Congress

Vienna, Austria

November

4–7

2026

SNMMI 2026 Theranostics Conference

Bethesda, MD

February

1–4

2027

DOE National Isotope Summit

Washington, DC

February

4–6

2027

SNMMI 2027 Mid-Winter Meeting

San Fransisco, CA

Save the date for the DOE National Isotope Summit

U.S. Department of Energy Advances Domestic Capabilities for Producing Quantum Materials

DOE Expands Stable Isotope Production Capabilities at Oak Ridge National Laboratory

Isotope Product Catalog

Translating Research to Applications

Medical Isotopes

Technical Resources

NIDC News

DOE Isotope Program Highlights

To Advance Cancer Therapy, University Starts Producing Terbium-161

Improving Large-Scale Domestic Production of Americium-241, a Critical Component in Smoke Detectors and Nuclear Batteries

Astatine Paving the Way for a New Era in Cancer Radiopharmaceuticals

Killing Cancer with Radioactive Nanocrystals

Upcoming Events

EANM'26 Annual Congress

SNMMI 2026 Theranostics Conference

DOE National Isotope Summit

SNMMI 2027 Mid-Winter Meeting

Recent Publications

Production and Purification of Terbium-155 Using Natural Gadolinium Targets

Production and purification of research scale 161Tb using cation-exchange semi-preparative HPLC for radiopharmaceutical applications

Probing the Redox Reactivity of Alkyl Bound Astatine: A Study on the Formation and Cleavage of a Stable At–C Bond