The U.S. Department of Energy Isotope Program has ramped up production of high specific activity cadmium-109 (Cd-109) to address a recent surge in demand as end users seek to diversify their supply chains.
Spring Stakeholder Meetings 2024
The DOE IP invites you to join us for one-on-one stakeholder meetings on May 28, May 29, 2024, and June 10, 2024.
DOE Seal
The DOE Isotope Program (DOE IP) is participating in the recently announced DOE Office of Science (SC) Reaching a New Energy Sciences Workforce (RENEW) initiative

DOE Isotope Program Highlights

Image courtesy of Bobba, K.N., et al., Evaluation of cerium/lanthanum-134 as a PET imaging theranostic pair for 225Ac alpha radiotherapeutics. Journal of Nuclear Medicine 64, 7 (2023). Radiopharmaceuticals based on cerium/lanthanum-134 have promise for prostate cancer imaging and therapy. At right, tumors show high tumor uptake of cerium-134. At left, a comparison of cerium-134 and actinium-225 shows a similar pattern of uptake in most tissues (note the tumor tissue on the leg).

Transforming Cancer Diagnosis and Treatment with Cerium/Lanthanum-134

Researchers advance the use of cerium/lanthanum-134 for medical scans in actinium-225 cancer therapy.
Image courtesy of Brookhaven National Laboratory Depiction of a titanium-44/scandium-44 generator. The generator consists of a hydroxamate-based resin undergoing scandium-44 elution with hydrochloric acid.

Scientists Identify an Alternative System for Producing the Medical Isotope Scandium-44

An easy-to-use system can increase the availability of PET imaging agents to more patients.
This image depicts a binding molecule delivering radium-223 to a cancer cell. Image courtesy of Adam Malin, Oak Ridge National Laboratory.

Capturing the Chemistry of Radium-223 for Cancer Treatment

Until now, there have been few efforts to get information on how radium binds with known chelators.
Image courtesy of Jonathan Engle, University of Wisconsin. Summary of the production process for radioisotopes of scandium using recyclable, enriched calcium.

Researchers Improve Production for Short-Lived Scandium Radioisotopes

Hard to produce in quantities and purities appropriate for human use, scandium radioisotopes have potential for imaging cancer.