February Isotope Spotlights

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The DOE Isotope Program maintains an extensive inventory of radioactive and stable isotopes. Below are a select few that are currently in inventory and ready to dispense to meet your research and commercial needs. For a complete list visit our product catalog.

 


Actinium-225/bismuth-213 generator

An actinium-225/bismuth-213 (Ac-225/Bi-213) generator provides the radioactive component in emerging cancer treatment options for leukemia, lymphomas, and micro-metastatic carcinomas.This generator produces Bi-213, an alpha-emitting isotope with high potency for destroying cancer cells while minimizing damage to surrounding healthy tissue.

Actinium-225/bismuth-213 generators are assembled at Oak Ridge and Brookhaven National Laboratories using Ac-225 produced through proton bombardment on a natural thorium target. 

The Ac-225/Bi-213 generator can be ordered in mCi quantities and is housed in 1.25 inch lead pig with inlet/outlet holes.

 

 


Cerium-139

Cerium-139 (Ce-139) is used in mixed calibration sources and to determine attenuation maps for Single Photon Emission Computed Tomography (SPECT) in medical diagnosis. It also can be used as a tracer instead of short lived Cerium-134. 

Ce-139 is produced in the Isotope Production Facility at Los Alamos National Laboratory through proton bombardment on a lanthanum target. 

Cerium-139 can be ordered in mCi quantities as Cerium (III) in 0.5 N HCl. 

 

 


Cadmium-109

The DOE Isotope Program has ramped up production of high specific activity cadmium-109 (Cd-109) to address a recent surge in demand as end users seek to diversify their supply chains.

Most commonly used as a source for X-ray fluorescence imaging and in environmental research, Cd-109 (half-life of 461.4 days to silver-109) is produced at the Isotope Production Facility at Los Alamos National Laboratory through proton bombardment of an indium target. The specific activity is expected to be >50 Ci/g. It also possesses a radionuclidic purity of >99% (excluding Cd-113m and Cd-115m).

Cadmium-109 can be ordered in mCi quantities as cadmium (II) in 0.1 N HCl.

 


Arsenic-73

Arsenic-73 (As-73) is commonly used as a radiotracer for medical research. As-73 has a half-life of 80.3 days decaying to germanium-73, and is produced at the Isotope Production Facility at Los Alamos National Laboratory through proton bombardment on a germanium target. The radionuclidic purity is >99% (exclusive of As-74). 

Arsenic-73 can be ordered in mCi quantities as Arsenic (V) in 0.1 N HCl.  

 

 

 

 


Lead-203

Lead-203 (Pb-203) has drawn interest as a Single Photon Emission Computed Tomography (SPECT) imaging isotopic analogue to the therapeutic lead-212, an alpha-emitter. Its addition to the NIDC Catalog establishes a theranostic matched pair of isotopes. The DOE Isotope Program is filling a gap in the market as there are currently no other domestic producers.

Pb-203 is routinely available in millicurie quantities. The final product is distributed in a 1.5 mL micro-centrifuge tube with a ≥98% radionuclidic purity.