Development of an autonomous solvent extraction system to isolate astatine-211 from dissolved cyclotron bombarded bismuth targets

Cyclotron-produced astatine-211 (²¹¹At) shows tremendous promise in targeted alpha therapy (TAT) applications due to its attractive half-life and its 100% α-emission from nearly simultaneous branched alpha decay. Astatine-211 is produced by alpha beam bombardment of naturally monoisotopic bismuth metal (²⁰⁹Bi) via the (α, 2n) reaction. In order to isolate the small mass of ²¹¹At (specific activity = 76 GBq·µg⁻¹) from several grams of acid-dissolved Bi metal, a manual milliliter-scale solvent extraction process using diisopropyl ether (DIPE) is routinely performed at the University of Washington. As this process is complex and time-consuming, we have developed a fluidic workstation that can perform the method autonomously.