| NIDC: National Isotope Development Center

Recordings Now Available: DOE IP Virtual Seminar Series

The DOE Isotope Program hosted three virtual seminars focused on the following emerging medical isotopes: astatine-211, lead-203/212, and cerium-134. If you were unable to attend, or want to watch it again, you can now access the meeting recordings and presentations for your convenience.

DOE Isotope Program and QSA Global Inc. partner for domestic production of iridium-192

The U.S. Department of Energy (DOE) Isotope Program and QSA Global Inc. announced a joint product development agreement to initiate domestic production of iridium-192 (Ir-192), a critical isotope for industrial gamma ray radiography.

Isotope Product Catalog

With 225+ isotopes available for purchase, the U.S. Department of Energy Isotope Program is the world leader in quality, purity, and availability of the most sought after and rare isotopes.

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DOE Isotope Program Welcomes Texas A&M University Cyclotron Institute to the University Isotope Network

The DOE Isotope Program is excited to announce the addition of the Texas A&M University Cyclotron Institute to the University Isotope Network. Supported by DOE and the State of Texas funding, the Cyclotron Institute has developed Astatine-211 (At-211) production which is now available for routine regional distribution through the NIDC product catalog. The Texas A&M…

Announcing domestic supply of lead-203

The U.S. Department of Energy Isotope Program is pleased to announce lead-203 (Pb-203) has been added to our catalog and is available for purchase. Pb-203 has drawn interest as a SPECT imaging isotope analogue to the therapeutic Pb-212, an alpha-emitter. Its addition to the NIDC Catalog establishes a theranostic matched pair of isotopes. Pb-203 will be shipped on a monthly basis with the first…

SPECT image of 0.8 mCi of Pb-203 as PbCl2 in solution. The material was placed in a small device used to gauge resolution capabilities of the imaging camera against the source isotope. Image courtesy: Suzanne E. Lapi and Shefali Saini, UAB

Translating Research to Applications

Get a behind-the-scenes look at the production of isotopes across the Department's facilities that are critical to everyday applications, particularly in the medical arena.

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Medical Isotopes

With more than 35 medically relevant isotopes available and others under investigation, the NIDC is committed to supplying the world with the highest quality isotopes for medical use.

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NIDC News

DOE Isotope Program Welcomes Texas A&M University Cyclotron Institute to the University Isotope Network

The DOE Isotope Program is excited to announce the addition of the Texas A&M University Cyclotron Institute to the University Isotope Network.

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Recordings Now Available: DOE IP Virtual Seminar Series

The DOE Isotope Program hosted three virtual seminars focused on the following emerging medical isotopes: astatine-211, lead-203/212, and cerium-134.

Learn More

Ir-192 Product Development Agreement image

DOE Isotope Program and QSA Global Inc. partner for domestic production of iridium-192

The U.S. Department of Energy (DOE) Isotope Program and QSA Global Inc. announced a joint product development agreement to initiate domestic production of iridium-192.

Learn More

DOE Isotope Program Highlights

Image courtesy of Bobba, K.N., et al., Evaluation of cerium/lanthanum-134 as a PET imaging theranostic pair for 225Ac alpha radiotherapeutics. Journal of Nuclear Medicine 64, 7 (2023). Radiopharmaceuticals based on cerium/lanthanum-134 have promise for prostate cancer imaging and therapy. At right, tumors show high tumor uptake of cerium-134. At left, a comparison of cerium-134 and actinium-225 shows a similar pattern of uptake in most tissues (note the tumor tissue on the leg).

Transforming Cancer Diagnosis and Treatment with Cerium/Lanthanum-134

October 25, 2023

Researchers advance the use of cerium/lanthanum-134 for medical scans in actinium-225 cancer therapy.

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Image courtesy of Brookhaven National Laboratory Depiction of a titanium-44/scandium-44 generator. The generator consists of a hydroxamate-based resin undergoing scandium-44 elution with hydrochloric acid.

Scientists Identify an Alternative System for Producing the Medical Isotope Scandium-44

August 29, 2023

An easy-to-use system can increase the availability of PET imaging agents to more patients.

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This image depicts a binding molecule delivering radium-223 to a cancer cell. Image courtesy of Adam Malin, Oak Ridge National Laboratory.

Capturing the Chemistry of Radium-223 for Cancer Treatment

August 11, 2023

Until now, there have been few efforts to get information on how radium binds with known chelators.

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Image courtesy of Jonathan Engle, University of Wisconsin. Summary of the production process for radioisotopes of scandium using recyclable, enriched calcium.

Researchers Improve Production for Short-Lived Scandium Radioisotopes

August 1, 2023

Hard to produce in quantities and purities appropriate for human use, scandium radioisotopes have potential for imaging cancer.

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Recordings Now Available: DOE IP Virtual Seminar Series

DOE Isotope Program and QSA Global Inc. partner for domestic production of iridium-192

Isotope Product Catalog

DOE Isotope Program Welcomes Texas A&M University Cyclotron Institute to the University Isotope Network

Announcing domestic supply of lead-203

Translating Research to Applications

Medical Isotopes

Technical Resources

NIDC News

DOE Isotope Program Highlights

Transforming Cancer Diagnosis and Treatment with Cerium/Lanthanum-134

Scientists Identify an Alternative System for Producing the Medical Isotope Scandium-44

Capturing the Chemistry of Radium-223 for Cancer Treatment

Researchers Improve Production for Short-Lived Scandium Radioisotopes

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Recent Publications

Photonuclear production of 47Ca for 47Ca/47Sc generator from natural CaCO3 targets

Effective therapy with Bismuth-212 labeled macroaggregated albumin in orthotopic mouse breast tumor models

Evaluation of 177 Lu and 47 Sc Picaga-Linked, Prostate-Specific Membrane Antigen-Targeting Constructs for Their Radiotherapeutic Efficacy and Dosimetry